Designability of lattice model heteropolymers
نویسندگان
چکیده
منابع مشابه
Designability of lattice model heteropolymers.
Protein folds are highly designable, in the sense that many sequences fold to the same conformation. In the present work we derive an expression for the designability in a 20-letter lattice model of proteins which, relying only on the central limit theorem, has a generality which goes beyond the simple model used in its derivation. This expression displays an exponential dependence on the energ...
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Proteins are an example of heteropolymers able to self-assemble in specific target structures. The self-assembly of designed artificial heteropolymers is still, to the best of our knowledge, not possible with control over the single chain self-assembling properties comparable to what natural proteins can achieve. What artificial heteropolymers lacks compared to bio-heteropolymers that grants th...
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Native protein folds often have a high degree of symmetry. We study the relationship between the symmetries of native proteins, and their designabilities – how many different sequences encode a given native structure. Using a two-dimensional lattice protein model based on hydrophobicity, we find that those native structures that are encoded by the largest number of different sequences have high...
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ژورنال
عنوان ژورنال: Physical Review E
سال: 2001
ISSN: 1063-651X,1095-3787
DOI: 10.1103/physreve.64.011904